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Do Antidepressants Increase Suicidality? Does The Black Box Warning Help or Hurt People?

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A black box warning was issued for antidepressants regarding concerns of suicidality. But do antidepressants cause suicide? What was the effect of the black box warning?

Because of the black box warnings (also known as boxed warnings) on antidepressants, many people think that antidepressants cause suicidal thinking, suicidal behavior, and suicide. The black box warning on antidepressants is, after all, the strongest warning the Food and Drug Administration (FDA) can place on a medication. However, the black box warning on antidepressants was authored almost 20 years ago, and we have learned a lot and have synthesized a lot of data since then. Does this more recent data indicate that antidepressants increase suicidality or cause suicides, and what can we learn from this new information? Should we be scared of the risk of suicidality with antidepressants? (TL;DR here.)


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